The Hypocholesterolemic Effect of Chloroquine in Rat

Original article


A. A. Abdel — Gayoum, S. S. Haider, F.M. Tash, K. Ghwarsha

Department of Biochemistry, Faculty of Medicine, A] —Arab Medical University, Benghazi, G.S.P.L.A.J.

Garyounis Medical Journal Vol. 17, No. 1-2. January/July l994:.55 -59


Female rats were injected with Chloroquine at dose of 10mg/Kg/day for ten days. The drug caused a significant reduction in the total serum cholesterol and phospholipids by 25% and 55%, respectively. Both HDL — chlesterol and VLDL + LDL — cholesterol fractions were lowered proportionally without altering the
percentages from total cholesterol. On the other hand, neither the hepatic cholesterol nor the phospholipid contents were affected by the Chloroquine treatment. The drug significantly depressed the ratio of esterified cholesterol: free cholesterol in both serum and liver tissue.

Keywords: The Hypocholesterolemic Effect of Chloroquine in Rat