TMC Experience in Aplastic Anaemia

Original article


Manal El-Habbash, Abdulfattah Elturki, Naji Jurnaz

Department of Oncology, Tripoli Medical Centre, Department of Medicine, Al Fateh University, Tripoli, Libya

JMJ Vol.8, No.2 (Summer) 2008:101-104


Study objective: To review Tripoli Medical Centre experience in aplastic anaemia (AA) in adults over seven years period. Design and Setting: Retrospective study of patients with (AA) registered in haematology-oncology department in Tripoli Medical Centre. Patients and Results: 17 patients were included in this study in the period between January 2000 and December 2006. The median age of patients was 27 years. 64% were males 82.4% presented with bleeding mainly mucosal site. History of jaundice was gathered in two patients. All patients are hepatitis B and C, and HIV negative. At presentation, mean haemoglobin was 7g/dl, mean WBC count was 2.3×10³/µL and mean platelets count was 20×10³/µL. Bone marrow study showed hypocellular features in all patients. According to (AA) classification, 5 patients have very severe (AA), 6 patients have severe (AA) and 6 patients have non-severe (AA). Mean duration of follow up was 19 months, 16 patients received cyclosporin 5 mg /kg/day as a single agent with or without predinsolone or oxymethalone.The response was assessed by number of admissions to hospital for blood transfusion and or severe sepsis. 37.5% of the patients showed complete response, 25% had partial response and 25% had no response. All patients who received cyclosporin developed gum hyperplasia, and two of them developed hypertension. Two patients received Erythropoietin without any response. Conclusion: AA affects young age group in our population, and males were affected more than female. Bleeding tendency was the most common presenting symptom and the overall response rate (partial and complete) to cyclosporin monotherapy was 62.5%.

Keywords: Aplastic anaemia, Cyclosporin, Complete blood count.