LibyaMed

Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration

. . Fetah KL, DiPardo BJ, Kongadzem EM, Tomlinson JS, Elzagheid A, Elmusrati M, Khademhosseini A, Ashammakhi N. . Small. 2019 Dec;15(50):e1901985. doi: 10.1002/smll.201901985. Epub 2019 Nov 13. Abstract Cancer is one of the leading causes of death worldwide, despite the large efforts to improve the understanding of cancer biology and development of treatments. The …

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Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data

. . Zghebi SS, Steinke DT, Rutter MK, Ashcroft DM. . BMJ Open. 2020 Jul 1;10(7):e033866. doi: 10.1136/bmjopen-2019-033866. Abstract OBJECTIVES: To compare the patterns of 18 physical and mental health comorbidities between people with recently diagnosed type 2 diabetes (T2D) and people without diabetes and how these change by age, gender and deprivation over time …

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Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region

. . Mestiri S, Boussetta S, Pakstis AJ, Elkamel S, Elgaaied ABA, Kidd KK, Cherni L. . Gene. 2021 Apr 20;777:145466. doi: 10.1016/j.gene.2021.145466. Epub 2021 Jan 29. Abstract The dopamine – related genes, like dopamine D2 receptor (DRD2) gene and ankyrin repeat and kinase domain containing 1 (ANKK1) gene are implicated in neurological functions. Some …

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Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

. . Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP. . Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20. Abstract Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends …

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Intimate partner violence among Arab women before and during the COVID-19 lockdown

. . El-Nimr NA, Mamdouh HM, Ramadan A, El Saeh HM, Shata ZN. . J Egypt Public Health Assoc. 2021 Jun 16;96:15. doi: 10.1186/s42506-021-00077-y. 2021 Dec. Abstract INTRODUCTION: Intimate partner violence (IPV) remains a serious human rights violation and an important health concern during the ongoing COVID-19 pandemic. The study aims to estimate the proportion …

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Integrative transnational analysis to dissect tuberculosis transmission events along the migratory route from Africa to Europe

. . Martínez-Lirola M, Jajou R, Mathys V, Martin A, Cabibbe AM, Valera A, Sola-Campoy PJ, Abascal E, Rodríguez-Maus S, Garrido-Cárdenas JA, Bonillo M, Chiner-Oms Á, López B, Vallejo-Godoy S, Comas I, Muñoz P, Cirillo DM, van Soolingen D, Pérez-Lago L, García de Viedma D. . J Travel Med. 2021 Jun 1;28(4):taab054. doi: 10.1093/jtm/taab054. Abstract …

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NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice

. . Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O’Reilly LA, Putoczki TL, Gerondakis S, Dimaline R, Caamano JH, Pritchard DM. . J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21. Abstract NF-κB signalling is an important factor in the development of inflammation-associated cancers. Mouse models of Helicobacter-induced gastric cancer and …

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β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat

. . Fortuin-de Smidt MC, Mendham AE, Hauksson J, Alhamud A, Stefanovski D, Hakim O, Swart J, Goff LM, Kahn SE, Olsson T, Goedecke JH. . Endocr Connect. 2021 May 19;10(5):550-560. doi: 10.1530/EC-21-0153. Abstract The role of ectopic fat, insulin secretion and clearance in the preservation ofβ-cell function in black African women with obesity who …

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Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana

. . Alotaibi A, Ebiloma GU, Williams R, Alfayez IA, Natto MJ, Alenezi S, Siheri W, AlQarni M, Igoli JO, Fearnley J, De Koning HP, Watson DG. . Molecules. 2021 Jun 26;26(13):3912. doi: 10.3390/molecules26133912. Abstract Ethanolic extracts of samples of temperate zone propolis, four from the UK and one from Poland, were tested against three …

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