Allosteric inhibition of [(125I)] ET-1 binding to ET(A) receptors by aldoxime and hydroxamic acid derivatives.
Original article English Ahmed M, Nencetti S, Mazzoni MR, Porchia F, Antonelli F, Lapucci A. Department of Pharmaceutical Chemistry, Garyounis University, Benghazi, Libya. Med Chem. 2008 Jul;4(4):298-308. Abstract Endothelin-1 (ET-1), a potent vasoconstrictor peptide, exerts its physiological effects by binding and activating specific G protein-coupled receptors, named ET(A) and ET(B). An unique property of ET-1 …