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The effects of short and long-term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance.

Original article English Beshyah SA, Henderson A, Niththyananthan R, Skinner E, Anyaoku V, Richmond W, Sharp P, Johnston DG. Unit of Metabolic Medicine, St. Mary’s Hospital Medical School, Paddington, London, United Kingdom. J Clin Endocrinol Metab. 1995 Feb;80(2):356-63. Abstract The effects of replacement with biosynthetic human GH on carbohydrate tolerance and lipid metabolism were studied …

The effects of short and long-term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. Read More »

The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults.

Original article English Beshyah SA, Kyd P, Thomas E, Fairney A, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital and Medical School, London, UK. Clin Endocrinol (Oxf). 1995 Mar;42(3):249-54. Abstract OBJECTIVE: Short-term GH replacement in hypopituitary adults increases bone turnover; data on the consequences of longer-term GH treatment are limited. We report on the …

The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults. Read More »

Comparison of measurements of body composition by total body potassium, bioimpedance analysis, and dual-energy X-ray absorptiometry in hypopituitary adults before and during growth hormone treatment.

Original article English Beshyah SA, Freemantle C, Thomas E, Johnston DG. Unit of Metabolic Medicine, St. Mary’s Hospital Medical School, Paddington, London. Am J Clin Nutr. 1995 Jun;61(6):1186-94. Abstract We compared fat-free mass (FFM) and percentage body fat mass (BFM) values derived from total body potassium (TBK), bioelectrical impedance analysis (BIA), and dualenergy X-ray absorptiometry …

Comparison of measurements of body composition by total body potassium, bioimpedance analysis, and dual-energy X-ray absorptiometry in hypopituitary adults before and during growth hormone treatment. Read More »

Beta-cell function in hypopituitary adults before and during growth hormone treatment.

Original article English Beshyah SA, Gelding SV, Andres C, Johnston DG, Gray IP. Unit of Metabolic Medicine, St Mary’s Hospital Medical School, London, U.K. Clin Sci (Lond). 1995 Sep;89(3):321-8. Abstract 1. We studied beta-cell function in 40 hypopituitary adults and in 36 matched control subjects. Hypopituitary patients were studied again at 1, 3 and 6 …

Beta-cell function in hypopituitary adults before and during growth hormone treatment. Read More »

Psychiatric aspects of hypopituitarism in adults.

Letter English Lynch S, Beshyah S, Merson S. J R Soc Med. 1995 Oct;88(10):603-4. Abstract Keywords: Psychiatric aspects of hypopituitarism in adults. Link/DOI: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8537956

National crash call number is needed.

Letter English Beshyah SA, Schiff R, al-Jehani FS. BMJ. 1996 Aug 17;313(7054):429. Abstract Keywords: National crash call number is needed. Link/DOI:

Effects of four years’ treatment with biosynthetic human growth hormone (GH) on body composition in GH-deficient hypopituitary adults.

Original article English Al-Shoumer KA, Page B, Thomas E, Murphy M, Beshyah SA, Johnston DG. Unit of Metabolic Medicine, Imperial College School of Medicine at St Mary’s Hospital, London, UK. Eur J Endocrinol. 1996 Nov;135(5):559-67. Abstract Short-term trials of growth hormone (GH) substitution in hypopituitary adults have shown beneficial effects on body composition. To evaluate …

Effects of four years’ treatment with biosynthetic human growth hormone (GH) on body composition in GH-deficient hypopituitary adults. Read More »

Abnormal carotid arterial wall dynamics in symptom-free hypopituitary adults.

Original article English Markussis V, Beshyah SA, Fisher C, Parker KH, Nicolaides AN, Johnston DG. Unit of Metabolic Medicine, Imperial College of Science, Technology and Medicine, London, UK. Eur J Endocrinol. 1997 Feb;136(2):157-64. Abstract OBJECTIVE: Although vascular mortality is increased in hypopituitary adults on routine replacement, there are limited data on the atherosclerotic process during …

Abnormal carotid arterial wall dynamics in symptom-free hypopituitary adults. Read More »

Effects of four years’ treatment with biosynthetic human growth hormone (GH) on glucose homeostasis, insulin secretion and lipid metabolism in GH-deficient adults.

Original article English al-Shoumer KA, Gray R, Anyaoku V, Hughes C, Beshyah S, Richmond W, Johnston DG. Unit of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, St Mary’s Hospital, London, UK. Clin Endocrinol (Oxf). 1998 Jun;48(6):795-802. Abstract OBJECTIVE: To study the effects of long-term growth hormone (GH) treatment on lipid metabolism and carbohydrate …

Effects of four years’ treatment with biosynthetic human growth hormone (GH) on glucose homeostasis, insulin secretion and lipid metabolism in GH-deficient adults. Read More »

How much, and by what mechanisms, does growth hormone replacement improve the quality of life in GH-deficient adults?

Review English Chrisoulidou A, Kousta E, Beshyah SA, Robinson S, Johnston DG. Division of Medicine, Imperial College School of Medicine, St. Mary’s Hospital, London, UK. Baillieres Clin Endocrinol Metab. 1998 Jul;12(2):261-79. Abstract The majority of studies (but not all) have demonstrated that adults with hypopituitarism of both childhood and adult onset have a diminished quality …

How much, and by what mechanisms, does growth hormone replacement improve the quality of life in GH-deficient adults? Read More »