LibyaMed

Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells

. . Ibrahim AB, Zaki HF, Wadie W, Omran MM, Shouman SA. . Cancer Manag Res. 2019 Nov 28;11:10011-10028. doi: 10.2147/CMAR.S218668. 2019. Abstract PURPOSE: Tamoxifen (TAM) is a non-steroidal antiestrogen drug, used in the prevention and treatment of all stages of hormone-responsive breast cancer. Simvastatin (SIM) is a lipid-lowering agent and has been shown to …

Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells Read More »

Characteristics of Laryngeal Osteosarcoma: A Critical Review

. . Mäkitie AA, Devaney KO, Baujat B, Almangush A, Ferlito A. . Oncol Ther. 2020 Jun;8(1):33-44. doi: 10.1007/s40487-020-00110-8. Epub 2020 Feb 11. Abstract Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a …

Characteristics of Laryngeal Osteosarcoma: A Critical Review Read More »

COVID-19 on the Nile: Review on the Management and Outcomes of the COVID-19 Pandemic in the Arab Republic of Egypt from February to August 2020

. . Gaye YE, Agbajogu C, El Oakley R. . Int J Environ Res Public Health. 2021 Feb 8;18(4):1588. doi: 10.3390/ijerph18041588. Abstract As the world fights the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the World Health Organization (WHO) reports that over 17 million people globally were infected …

COVID-19 on the Nile: Review on the Management and Outcomes of the COVID-19 Pandemic in the Arab Republic of Egypt from February to August 2020 Read More »

Modulatory effects of L-carnitine on tamoxifen toxicity and oncolytic activity: in vivo study

. . Ibrahim AB, Mansour HH, Shouman SA, Eissa AA, Abu El Nour SM. . Hum Exp Toxicol. 2014 Sep;33(9):968-79. doi: 10.1177/0960327113506237. Epub 2013 Dec 17. Abstract The aim of this study was to investigate the protective effect of L-carnitine (L-CAR) in tamoxifen (TAM)-induced toxicity and antitumor activity. Adult female rats were randomly divided into …

Modulatory effects of L-carnitine on tamoxifen toxicity and oncolytic activity: in vivo study Read More »

Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice

. . Adwas AA, Elkhoely AA, Kabel AM, Abdel-Rahman MN, Eissa AA. . J Infect Chemother. 2016 Jan;22(1):36-43. doi: 10.1016/j.jiac.2015.10.001. Epub 2015 Nov 19. Abstract Doxorubicin (DOX) is a broad-spectrum antitumor antibiotic used in treatment of cancer. Its effect may be complicated by increased risk of cardiotoxicity. It was suggested that natural compounds with anticancer …

Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice Read More »

Structural and functional abnormalities of hepatic tissues in male Wistar rats fed hyperwhey and super amino anabolic protein

. . Ali DA, El-Sayyad HI, Moftah OA, Chilibeck PD. . Nutrition. 2016 Jul-Aug;32(7-8):840-8. doi: 10.1016/j.nut.2016.01.017. Epub 2016 Feb 8. Abstract OBJECTIVE: Athletes and bodybuilders consume high-protein supplements to obtain energy and enhance the development and strength of their muscles. Over time, different investigations have revealed dysfunctions of their body organs. There are contradictions among …

Structural and functional abnormalities of hepatic tissues in male Wistar rats fed hyperwhey and super amino anabolic protein Read More »

Studies on the effects of titanate and silane coupling agents on the performance of poly (methyl methacrylate)/barium titanate denture base nanocomposites

. . Elshereksi NW, Ghazali MJ, Muchtar A, Azhari CH. . J Dent. 2017 Jan;56:121-132. doi: 10.1016/j.jdent.2016.11.012. Epub 2016 Dec 1. Abstract OBJECTIVES: This study aimed to fabricate and characterise silanated and titanated nanobarium titanate (NBT) filled poly(methyl methacrylate) (PMMA) denture base composites and to evaluate the behaviour of a titanate coupling agent (TCA) as …

Studies on the effects of titanate and silane coupling agents on the performance of poly (methyl methacrylate)/barium titanate denture base nanocomposites Read More »

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion

. . Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S. . Front Physiol. 2018 Feb 9;9:51. doi: 10.3389/fphys.2018.00051. 2018. Abstract Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated …

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion Read More »

The prognostic value of immune checkpoints in oral squamous cell carcinoma

. . Sieviläinen M, Almahmoudi R, Al-Samadi A, Salo T, Pirinen M, Almangush A. . Oral Dis. 2019 Sep;25(6):1435-1445. doi: 10.1111/odi.12991. Epub 2018 Nov 12. Abstract BACKGROUND: Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to …

The prognostic value of immune checkpoints in oral squamous cell carcinoma Read More »