LibyaMed

Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells

. . Ibrahim AB, Zaki HF, Wadie W, Omran MM, Shouman SA. . Cancer Manag Res. 2019 Nov 28;11:10011-10028. doi: 10.2147/CMAR.S218668. 2019. Abstract PURPOSE: Tamoxifen (TAM) is a non-steroidal antiestrogen drug, used in the prevention and treatment of all stages of hormone-responsive breast cancer. Simvastatin (SIM) is a lipid-lowering agent and has been shown to …

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Characteristics of Laryngeal Osteosarcoma: A Critical Review

. . Mäkitie AA, Devaney KO, Baujat B, Almangush A, Ferlito A. . Oncol Ther. 2020 Jun;8(1):33-44. doi: 10.1007/s40487-020-00110-8. Epub 2020 Feb 11. Abstract Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a …

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High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion

. . Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S. . Front Physiol. 2018 Feb 9;9:51. doi: 10.3389/fphys.2018.00051. 2018. Abstract Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated …

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion Read More »

The COVID-19 pandemic and E-learning: challenges and opportunities from the perspective of students and instructors

. . Maatuk AM, Elberkawi EK, Aljawarneh S, Rashaideh H, Alharbi H. . J Comput High Educ. 2021 May 3:1-18. doi: 10.1007/s12528-021-09274-2. Online ahead of print. Abstract The spread of COVID-19 poses a threat to humanity, as this pandemic has forced many global activities to close, including educational activities. To reduce the spread of the …

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Biopsy quality is essential for preoperative prognostication in oral tongue cancer

. . Bello IO, Wennerstrand PM, Suleymanova I, Siponen M, Qannam A, Nieminen P, Leivo I, Almangush A, Salo T. . APMIS. 2021 Mar;129(3):118-127. doi: 10.1111/apm.13104. Epub 2020 Dec 28. Abstract A role for incisional biopsy in preoperative prognostication is increasingly being advocated in oral tongue squamous cell carcinomas (OTSCC). Biopsies at two locations were …

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Knowledge, Attitudes, and Perceptions of the Arabic-Speaking Community in Sydney, Australia, toward the Human Papillomavirus (HPV) Vaccination Program: A Qualitative Study

. . Netfa F, King C, Davies C, Rashid H, Tashani M, Booy R, Skinner SR. . Vaccines (Basel). 2021 Aug 24;9(9):940. doi: 10.3390/vaccines9090940. Abstract BACKGROUND: Little is known about acceptability of the human papillomavirus (HPV) vaccine among parents of adolescents from culturally and linguistically diverse backgrounds in Australia. This study aimed to explore the …

Knowledge, Attitudes, and Perceptions of the Arabic-Speaking Community in Sydney, Australia, toward the Human Papillomavirus (HPV) Vaccination Program: A Qualitative Study Read More »

The prognostic value of immune checkpoints in oral squamous cell carcinoma

. . Sieviläinen M, Almahmoudi R, Al-Samadi A, Salo T, Pirinen M, Almangush A. . Oral Dis. 2019 Sep;25(6):1435-1445. doi: 10.1111/odi.12991. Epub 2018 Nov 12. Abstract BACKGROUND: Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to …

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Safety evaluation of naringenin upon experimental exposure on rat gastrointestinal epithelium for novel optimal drug delivery

. . Surampalli G, Nanjwade BK, Patil PA. . Drug Deliv. 2016;23(2):512-24. doi: 10.3109/10717544.2014.923957. Epub 2014 Jun 17. Abstract OBJECTIVE: To assess the effect of naringenin on the intestinal biochemical composition, function and histology for gastrointestinal toxicity since it has not yet been adequately exploited for safety through standard assays. METHODS: Here, we describe naringenin …

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Response of Parathyroid Hormone to Vitamin D Deficiency in Otherwise Healthy Individuals

. . Malik MZ, Latiwesh OB, Nouh F, Hussain A, Kumar S, Kaler J. . Cureus. 2020 Aug 15;12(8):e9764. doi: 10.7759/cureus.9764. Abstract Background and objectives Vitamin D deficiency is a global public health issue, which affects people of all ages and ethnicities. However, severe deficiency seems to be more prevalent in the Middle East and …

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