The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad
. . Emhemmed F, Azouaou SA, Hassan S, Lefevbre R, Désaubry L, Muller CD, Fuhrmann G. . Toxicol In Vitro. 2019 Oct;60:27-35. doi: 10.1016/j.tiv.2019.04.025. Epub 2019 Apr 25. Abstract The molecular pathways by which flavagline derivatives exert their cytotoxicity against various cancer cell types are well documented, while the mechanisms that prevent their cytotoxic effects …