Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites
. . Robertson J, Ungogo MA, Aldfer MM, Lemgruber L, McWhinnie FS, Bode BE, Jones KL, Watson AJB, de Koning HP, Burley GA. . ChemMedChem. 2021 Aug 6. doi: 10.1002/cmdc.202100509. Online ahead of print. Abstract A selective mono-N-arylation strategy of amidines under Chan-Lam conditions is described. During the reaction optimization phase, the isolation of a …