LibyaMed

Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents

. . Mohamed SS, Tamer AR, Bensaber SM, Jaeda MI, Ermeli NB, Allafi AA, Mrema IA, Erhuma M, Hermann A, Gbaj AM. . Naunyn Schmiedebergs Arch Pharmacol. 2013 Sep;386(9):813-22. doi: 10.1007/s00210-013-0883-y. Epub 2013 May 26. Abstract A series of sulfanilamide Schiff base derivatives (1 to 15) have been designed as potential antitubulin agents depending on …

Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents Read More »

in Silico investigation of the structural requirements for the AMPA receptor antagonism by quinoxaline derivatives

. . Azam F, Abugrain IM, Sanalla MH, Elnaas RF, Rajab IA. . Bioinformation. 2013 Oct 16;9(17):864-9. doi: 10.6026/97320630009864. 2013. Abstract Glutamate receptors have been implicated in various neurological disorders and their antagonism offers a suitable approach for the treatment of such disorders. The field of drug design and discovery aims to find best medicines …

in Silico investigation of the structural requirements for the AMPA receptor antagonism by quinoxaline derivatives Read More »

High-affinity selective inhibitor against phospholipase A2 (PLA2): a computational study

. . Chinnasamy S, Chinnasamy S, Muthusamy K. . J Recept Signal Transduct Res. 2016;36(2):111-8. doi: 10.3109/10799893.2015.1056306. Epub 2015 Sep 30. Abstract Phospholipase A2 (PLA2) is the most abundant protein found in snake venom. PLA2 induces a variety of pharmacological effects such as neurotoxicity, myotoxicity and cardiotoxicity as well as anticoagulant, hemolytic, anti-platelet, hypertensive, hemorrhagic …

High-affinity selective inhibitor against phospholipase A2 (PLA2): a computational study Read More »

Histological study on the heart ventricle of Egyptian bovines (Bos aegyptiacus)

. . Emam MA, Abugherin B. . Open Vet J. 2020 Jan;9(4):281-286. doi: 10.4314/ovj.v9i4.1. Epub 2019 Oct 20. Abstract BACKGROUND: The heart ventricles have thicker walls than atrium as they pump blood through blood vessels into all body organs. AIM: This study aimed to describe the histological changes of the heart ventricles in Egyptian bovine …

Histological study on the heart ventricle of Egyptian bovines (Bos aegyptiacus) Read More »

Morphological Re-Description and 18 S rDNA Sequence Confirmation of the Pinworm Aspiculuris tetraptera (Nematoda, Heteroxynematidae) Infecting the Laboratory Mice Mus musculus

. . Abdel-Gaber R, Abdel-Ghaffar F, Al Quraishy S, Morsy K, Saleh R, Mehlhorn H. . J Nematol. 2018 Sep 3;50(2):117-132. doi: 10.21307/jofnem-2018-026. Abstract Aspiculuris tetraptera is a heteroxynematid nematoda infecting most of the laboratory animals, occasionally mice which represent the mostly used animal for biological, medical, and pharmacological studies. The present study aimed to …

Morphological Re-Description and 18 S rDNA Sequence Confirmation of the Pinworm Aspiculuris tetraptera (Nematoda, Heteroxynematidae) Infecting the Laboratory Mice Mus musculus Read More »

Rituximab increases the cytotoxicities of vincristine and hydroxyurea through caspase-dependent and caspase-independent cell death, respectively

. . Tabal S, Elbanani A, Deyab M, Abulayha A. . Cancer Biother Radiopharm. 2015 Apr;30(3):125-31. doi: 10.1089/cbr.2014.1769. Epub 2015 Feb 25. Abstract In the treatment of B cell non-Hodgkin’s lymphoma, rituximab is used in combination with different chemotherapeutics to improve its efficacy, but the mechanisms involved are not fully understood. The authors examined the …

Rituximab increases the cytotoxicities of vincristine and hydroxyurea through caspase-dependent and caspase-independent cell death, respectively Read More »

GC-MS and GC-IR Analyses of the Methoxy-1-n-pentyl-3-(1-naphthoyl)-indoles: Regioisomeric Designer Cannabinoids

. . Thaxton-Weissenfluh A, Belal TS, DeRuiter J, Smith F, Abiedalla Y, Neel L, Abdel-Hay KM, Clark CR. . J Chromatogr Sci. 2018 Oct 1;56(9):779-788. doi: 10.1093/chromsci/bmy059. Abstract The indole ring regioisomeric methoxy-1-n-pentyl-3-(1-naphthoyl)-indoles represent indole ring-substituted analogs of the synthetic cannabinoid JWH-018. The electron ionization mass spectra show equivalent regioisomeric major fragments resulting from cleavage …

GC-MS and GC-IR Analyses of the Methoxy-1-n-pentyl-3-(1-naphthoyl)-indoles: Regioisomeric Designer Cannabinoids Read More »

Penalised logistic regression and dynamic prediction for discrete-time recurrent event data

. . Elgmati E, Fiaccone RL, Henderson R, Matthews JN. . Lifetime Data Anal. 2015 Oct;21(4):542-60. doi: 10.1007/s10985-015-9321-4. Epub 2015 Jan 28. Abstract We consider methods for the analysis of discrete-time recurrent event data, when interest is mainly in prediction. The Aalen additive model provides an extremely simple and effective method for the determination of …

Penalised logistic regression and dynamic prediction for discrete-time recurrent event data Read More »

Aqua and Terra MODIS RSB calibration comparison using BRDF modeled reflectance

. . Chang T, Xiong X, Angal A, Wu A, Geng X. . IEEE Trans Geosci Remote Sens. 2017 Apr;55(4):2288-2298. doi: 10.1109/TGRS.2016.2641258. Epub 2017 Jan 16. Abstract The inter-comparison of MODIS reflective solar bands onboard Aqua and Terra is very important for assessment of each instrument’s calibration. One of the limitations is the lack of …

Aqua and Terra MODIS RSB calibration comparison using BRDF modeled reflectance Read More »