LibyaMed

MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis

. . Elmesmari A, Fraser AR, Wood C, Gilchrist D, Vaughan D, Stewart L, McSharry C, McInnes IB, Kurowska-Stolarska M. . Rheumatology (Oxford). 2016 Nov;55(11):2056-2065. doi: 10.1093/rheumatology/kew272. Epub 2016 Jul 13. Abstract OBJECTIVE: To test the hypothesis that miR-155 regulates monocyte migratory potential via modulation of chemokine and chemokine receptor expression in RA, and thereby …

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Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

. . Ugun-Klusek A, Tatham MH, Elkharaz J, Constantin-Teodosiu D, Lawler K, Mohamed H, Paine SM, Anderson G, John Mayer R, Lowe J, Ellen Billett E, Bedford L. . Cell Death Dis. 2017 Jan 5;8(1):e2531. doi: 10.1038/cddis.2016.443. Abstract The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy …

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Anatomic Variation in Morphometry of Human Coracoid Process among Asian Population

. . Fathi M, Cheah PS, Ahmad U, Nasir MN, San AA, Abdul Rahim E, Hussin P, Mahmud R, Othman F. . Biomed Res Int. 2017;2017:6307019. doi: 10.1155/2017/6307019. Epub 2017 Apr 6. Abstract Ethnic origin plays an important role in bone morphometry. Studies examining the influence of coracoid process have focused primarily on adults and …

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Cost-effectiveness of Humanitarian Pediatric Cardiac Surgery Programs in Low- and Middle-Income Countries

. . Cardarelli M, Vaikunth S, Mills K, DiSessa T, Molloy F, Sauter E, Bowtell K, Rivera R, Shin AY, Novick W. . JAMA Netw Open. 2018 Nov 2;1(7):e184707. doi: 10.1001/jamanetworkopen.2018.4707. Abstract IMPORTANCE: Endorsement of global humanitarian interventions is based on either proven cost-effectiveness or perceived public health benefits. The cost-effectiveness and long-term benefits of …

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Project ECHO: a Potential Best-Practice Tool for Training Healthcare Providers in Oral Cancer Screening and Tobacco Cessation

. . Nethan ST, Hariprasad R, Babu R, Kumar V, Sharma S, Mehrotra R. . J Cancer Educ. 2020 Oct;35(5):965-971. doi: 10.1007/s13187-019-01549-8. Abstract The oral cancer pandemic and inadvertent tobacco consumption have rendered timely oral cavity screening and tobacco cessation essential, skills which most healthcare providers (HCPs) lack. Project “Extension for Community Healthcare Outcomes” (ECHO) …

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Uterine Artery Embolization of Uterine Leiomyomas: Predictive MRI Features of Volumetric Response

. . Kurban LAS, Metwally H, Abdullah M, Kerban A, Oulhaj A, Alkoteesh JA. . AJR Am J Roentgenol. 2021 Apr;216(4):967-974. doi: 10.2214/AJR.20.22906. Epub 2021 Feb 17. Abstract OBJECTIVE. The purpose of this article was to evaluate MRI features of uterine leiomyomas that predict volumetric response after uterine artery embolization (UAE). MATERIALS AND METHODS. This …

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Disparities in pregnancy-related deaths: spatial and Bayesian network analyses of maternal mortality ratio in 54 African countries

. . Yaya S, Anjorin SS, Adedini SA. . BMJ Glob Health. 2021 Feb;6(2):e004233. doi: 10.1136/bmjgh-2020-004233. Abstract BACKGROUND: Maternal mortality remains a public health problem despite several global efforts. Globally, about 830 women die of pregnancy-related death per day, with more than two-third of these cases occurring in Africa. We examined the spatial distribution of …

Disparities in pregnancy-related deaths: spatial and Bayesian network analyses of maternal mortality ratio in 54 African countries Read More »

Novel combinatorial strategies for boosting the efficacy of immune checkpoint inhibitors in advanced breast cancers

. . Tolba MF, Elghazaly H, Bousoik E, Elmazar MMA, Tolaney SM. . Clin Transl Oncol. 2021 Oct;23(10):1979-1994. doi: 10.1007/s12094-021-02613-w. Epub 2021 Apr 19. Abstract The year 2019 witnessed the first approval of an immune checkpoint inhibitor (ICI) for the management of triple negative breast cancers (TNBC) that are metastatic and programmed death ligand (PD)-L1 positive. Extensive …

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Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer

. . Messeha SS, Zarmouh NO, Soliman KFA. . Nutrients. 2021 May 19;13(5):1718. doi: 10.3390/nu13051718. Abstract Investigating dietary polyphenolic compounds as antitumor agents are rising due to the growing evidence of the close association between immunity and cancer. Cancer cells elude immune surveillance for enhancing their progression and metastasis utilizing various mechanisms. These mechanisms include …

Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer Read More »