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Original article English Beshyah SA, Sharp PS, Gelding SV, Halliday D, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital Medical School, London, UK. Acta Endocrinol (Copenh). 1993 Aug;129(2):158-64. Abstract This study has investigated protein metabolism in adults with hypopituitarism before and after growth hormone (GH) replacement and in matched controls. Whole-body leucine turnover was …

Whole-body leucine turnover in adults on conventional treatment for hypopituitarism. Read More »

Original article English Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital and Medical School, London, UK. Clin Endocrinol (Oxf). 1994 Mar;40(3):383-91. Abstract OBJECTIVE: The importance of growth hormone (GH) for normal skeletal growth in childhood and adolescence is well established but much less is …

The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism. Read More »

Original article English Beshyah SA, Shahi M, Skinner E, Sharp P, Foale R, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital and Medical School, London, UK. Eur J Endocrinol. 1994 May;130(5):451-8. Abstract In the present study the effects of replacement with biosynthetic human growth hormone (GH) in a large group of hypopituitary adults on …

Cardiovascular effects of growth hormone replacement therapy in hypopituitary adults. Read More »

Original article English Lynch S, Merson S, Beshyah SA, Skinner E, Sharp P, Priest RG, Johnston DG. Academic Department of Psychiatry, St. Mary’s Hospital Medical School, London, UK. J R Soc Med. 1994 Aug;87(8):445-7. Abstract Forty-one adults with established hypopituitarism and deficiency of growth hormone (GHD) were compared to an age and sex-matched group with …

Psychiatric morbidity in adults with hypopituitarism. Read More »

Original article English Beshyah SA, Henderson A, Baynes C, Copping D, Richmond W, Johnston DG. Unit of Metabolic Medicine, St. Mary’s Hospital Medical School, London, UK. Horm Res. 1995;44(2):69-74. Abstract Twenty-six hypopituitary patients on conventional replacement therapy were compared with 31 matched normal controls. Plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities were measured …

Post-heparin plasma lipase activity in hypopituitary adults. Read More »

Original article English Rutherford OM, Beshyah SA, Schott J, Watkins Y, Johnston DG. Department of Physiology, St. Mary’s Hospital Medical School, London, U.K. Clin Sci (Lond). 1995 Jan;88(1):67-71. Abstract 1. Growth hormone-deficient hypopituitary adults often complain of weakness and fatigue. The cause of the fatigue is unknown but could be an increased proportion of fast, …

Contractile properties of the quadriceps muscle in growth hormone-deficient hypopituitary adults. Read More »

Original article English Beshyah SA, Shahi M, Foale R, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital and Medical School, London, UK. J Intern Med. 1995 Jan;237(1):35-42. Abstract OBJECTIVES. To study the cardiovascular effects of human growth hormone (GH) replacement therapy in adults. INTERVENTION. Biosynthetic human GH given in a daily dose of 0.04 …

Cardiovascular effects of prolonged growth hormone replacement in adults. Read More »

Original article English Beshyah SA, Freemantle C, Shahi M, Anyaoku V, Merson S, Lynch S, Skinner E, Sharp P, Foale R, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital Medical School, London, UK. Clin Endocrinol (Oxf). 1995 Jan;42(1):73-84. Abstract OBJECTIVES: The physiological role of growth hormone in adult life has recently attracted increased interest. …

Replacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults. Read More »

Original article English al-Shoumer KA, Beshyah SA, Niththyananthan R, Johnston DG. Unit of Metabolic Medicine, St. Mary’s Hospital Medical School, London, UK. Clin Endocrinol (Oxf). 1995 Jan;42(1):85-90. Abstract BACKGROUND AND OBJECTIVES: Excess impaired glucose tolerance and diabetes mellitus have been reported in hypopituitary adults on conventional replacement therapy including glucocorticoids. We investigated the effect of …

Effect of glucocorticoid replacement therapy on glucose tolerance and intermediary metabolites in hypopituitary adults. Read More »

Original article English Beshyah SA, Freemantle C, Thomas E, Rutherford O, Page B, Murphy M, Johnston DG. Unit of Metabolic Medicine, St Mary’s Hospital Medical School, Paddington, London, UK. Clin Endocrinol (Oxf). 1995 Feb;42(2):179-89. Abstract OBJECTIVES: The role of growth hormone in maintaining normal body composition and bone strength in adults has attracted much interest …

Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults. Read More »