LibyaMed

Association between pet ownership and cardiovascular risks and mortality: a systematic review and meta-analysis

. . El-Qushayri AE, Kamel AMA, Faraj HA, Vuong NL, Diab OM, Istanbuly S, Elshafei TA, Makram OM, Sattar Z, Istanbuly O, Mukit SAA, Elfaituri MK, Low SK, Huy NT. . J Cardiovasc Med (Hagerstown). 2020 May;21(5):359-367. doi: 10.2459/JCM.0000000000000920. Abstract The aim of the study was to determine the association between pet ownership and cardiovascular …

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Boosting transdermal delivery of atorvastatin calcium via o/w nanoemulsifying system: Two-step optimization, ex vivo and in vivo evaluation

. . Shaker DS, Ishak RAH, Elhuoni MA, Ghoneim AM. . Int J Pharm. 2020 Mar 30;578:119073. doi: 10.1016/j.ijpharm.2020.119073. Epub 2020 Jan 23. Abstract A nanoemulsion system was designed for Atorvastatin calcium (ATOR) transdermal delivery to overcome its poor bioavailability of (30%) resulting from the extensive first-pass effect and dissolution rate-limited in vivo absorption. Pseudo …

Boosting transdermal delivery of atorvastatin calcium via o/w nanoemulsifying system: Two-step optimization, ex vivo and in vivo evaluation Read More »

Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region

. . Mestiri S, Boussetta S, Pakstis AJ, Elkamel S, Elgaaied ABA, Kidd KK, Cherni L. . Gene. 2021 Apr 20;777:145466. doi: 10.1016/j.gene.2021.145466. Epub 2021 Jan 29. Abstract The dopamine – related genes, like dopamine D2 receptor (DRD2) gene and ankyrin repeat and kinase domain containing 1 (ANKK1) gene are implicated in neurological functions. Some …

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Integrative transnational analysis to dissect tuberculosis transmission events along the migratory route from Africa to Europe

. . Martínez-Lirola M, Jajou R, Mathys V, Martin A, Cabibbe AM, Valera A, Sola-Campoy PJ, Abascal E, Rodríguez-Maus S, Garrido-Cárdenas JA, Bonillo M, Chiner-Oms Á, López B, Vallejo-Godoy S, Comas I, Muñoz P, Cirillo DM, van Soolingen D, Pérez-Lago L, García de Viedma D. . J Travel Med. 2021 Jun 1;28(4):taab054. doi: 10.1093/jtm/taab054. Abstract …

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β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat

. . Fortuin-de Smidt MC, Mendham AE, Hauksson J, Alhamud A, Stefanovski D, Hakim O, Swart J, Goff LM, Kahn SE, Olsson T, Goedecke JH. . Endocr Connect. 2021 May 19;10(5):550-560. doi: 10.1530/EC-21-0153. Abstract The role of ectopic fat, insulin secretion and clearance in the preservation ofβ-cell function in black African women with obesity who …

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Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors

. . Koksal M, Dedeoglu-Erdogan A, Bader M, Gurdal EE, Sippl W, Reis R, Ozgurbuz M, Sipahi H, Celik T. . Arch Pharm (Weinheim). 2021 Aug;354(8):e2000469. doi: 10.1002/ardp.202000469. Epub 2021 May 9. Abstract To obtain new anti-inflammatory agents, recent studies have aimed to replace the carboxylate functionality of nonsteroidal anti-inflammatory drugs with less acidic heterocyclic …

Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors Read More »

Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana

. . Alotaibi A, Ebiloma GU, Williams R, Alfayez IA, Natto MJ, Alenezi S, Siheri W, AlQarni M, Igoli JO, Fearnley J, De Koning HP, Watson DG. . Molecules. 2021 Jun 26;26(13):3912. doi: 10.3390/molecules26133912. Abstract Ethanolic extracts of samples of temperate zone propolis, four from the UK and one from Poland, were tested against three …

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Multiple myeloma: therapeutic delivery of antibodies and aptamers

. . Pujol-Navarro N, Al Qaraghuli MM, Kubiak-Ossowska K, Alsaadi MM, Horne GA, Soutar RL, Paspali E, Ferro VA, Williams MT, Mulheran PA. . Ther Deliv. 2021 Sep 27. doi: 10.4155/tde-2021-0041. Online ahead of print. Abstract Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in …

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NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice

. . Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O’Reilly LA, Putoczki TL, Gerondakis S, Dimaline R, Caamano JH, Pritchard DM. . J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21. Abstract NF-κB signalling is an important factor in the development of inflammation-associated cancers. Mouse models of Helicobacter-induced gastric cancer and …

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice Read More »